aggregated alphasynuclein activates microglia a process

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Immunotherapy in Parkinson's Disease: Micromanaging Alpha ...

 · Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's …

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Microglial phenotypes and toll-like receptor 2 in the ...

Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (SN) of Parkinson's disease (PD) patients. Little is known, however, about the different phenotypes of microglia and how they change during disease progression, in the SN or in another brain region, like the hippocampus (HC), which is implicated in dementia and depression ...

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Alpha-synuclein - Wikipedia

Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. It is abundant in the brain while smaller amounts are found in the heart, muscle, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals.

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"Alpha-Synuclein Aggregates Activate the Nlrp3 ...

The presynaptic protein α-synuclein is the primary constituent of LBs and has been documented to play a major role in the pathogenesis of synucleinopathies. Recently, aggregated α-synuclein has been implicated in prompting microglia-mediated inflammation, a process associated with the progression of neuronal death in neurodegenerative disorders.

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Fcγ receptors are required for NF-κB signaling, microglial ...

 · Overexpression of alpha-synuclein (α-SYN), a protein which plays an important role in the pathogenesis of Parkinson's disease (PD), triggers microglial activation and adaptive immune responses, and leads to neurodegeneration of dopaminergic (DA) neurons. We hypothesized a link between the humoral adaptive immune response and microglial activation in α-SYN induced neurodegeneration.

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Autoantibodies to alpha‐synuclein in inherited Parkinson's ...

Aggregated α‐synuclein can trigger the activation of microglia; however, its capacity to induce production of specific autoantibodies (AAb) has not been assessed. In this study, we examined the presence of AAb against synuclein family members in the peripheral blood serum of PD patients and control individuals.

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α-Synuclein, a chemoattractant, directs microglial ...

 · α-Synuclein (α-syn) aggregates released from neurons activate microglia, leading to chronic neuroinflammation that causes damage to neurons in brains with synucleinopathies, such as Parkinson's disease (PD). However, little is known about the mechanism by which α-syn affects microglial activity, especially motility, and why microglia migrate toward the injured neurons and preferentially ...

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PLOS ONE: Triggering of Inflammasome by Aggregated α ...

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. It is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. Another feature is represented by the formation in these cells of inclusions called Lewy bodies (LB), principally constituted by fibrillar α-synuclein (αSyn).

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Nitrated alpha-synuclein-activated microglial profiling ...

This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alpha-synuclein (α-syn), a chief component of Lewy bodies that is released from affected dopaminergic neurons. α-Syn is nitrated during oxidative stress responses and in its aggregated form, induces inflammatory microglial functions.

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Aggregated alpha-synuclein activates microglia: a process ...

> The FASEB Journal> Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.

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KoreaMed Synapse

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005;19:533–542.

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Inflammation and α-Synuclein's Prion-like Behavior in ...

 · Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 19:533–542 PubMed CrossRef Google Scholar

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Alpha-synuclein: from secretion to dysfunction and death

 · The process of aSyn aggregation ... A direct effect of extracellular aSyn on microglia activation in vivo was described in mice injected with human wild-type aSyn protein ... Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005; 19:533 ...

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α-Synuclein Expression Modulates Microglial Activation ...

 · Recent Parkinson's disease research has focused on understanding the function of the cytosolic protein, α-synuclein, and its contribution to disease mechanisms. Within neurons, α-synuclein is hypothesized to have a role in regulating synaptic plasticity, vesicle release, and trafficking. In contrast, glial-expressed α-synuclein remains poorly described.

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Microglia as modulators of exosomal alpha-synuclein ...

Zhang, W. et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19, 533–542 (2005). CAS

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The role of Galectin-3 in α-synuclein-induced microglial ...

However, the signaling pathways involved in α-synuclein-mediated microglia activation are poorly understood. Galectin-3 is a member of a carbohydrate-binding protein family involved in cell activation and inflammation. Therefore, we investigated whether galectin-3 is involved in the microglia activation triggered by α-synuclein.

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α-Synuclein, a chemoattractant, directs microglial ...

 · α-Synuclein (α-syn) aggregates released from neurons activate microglia, leading to chronic neuroinflammation that causes damage to neurons in brains with synucleinopathies, such as Parkinson's disease (PD). However, little is known about the mechanism by which α-syn affects microglial activity, especially motility, and why microglia migrate toward the injured neurons and preferentially ...

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Concise Review: Modeling Neurodegenerative Diseases with ...

Microglia, the resident macrophage cells of the brain, have also emerged as key players in neuroinflammation. As primary human microglia from living subjects are normally not accessible to researchers, there is a pressing need for an alternative source of authentic human microglia which allows modeling of neurodegeneration in vitro.

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Nitrated alpha-synuclein-activated microglial profiling ...

This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alpha-synuclein (α-syn), a chief component of Lewy bodies that is released from affected dopaminergic neurons. α-Syn is ni-trated during oxidative stress responses and in its aggregated form, induces inflammatory microglial functions.

get price

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"Alpha-Synuclein Aggregates Activate the Nlrp3 ...

The presynaptic protein α-synuclein is the primary constituent of LBs and has been documented to play a major role in the pathogenesis of synucleinopathies. Recently, aggregated α-synuclein has been implicated in prompting microglia-mediated inflammation, a process associated with the progression of neuronal death in neurodegenerative disorders.

get price

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Studying neurodegenerative diseases in culture models

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia. J Neuroinflammation. 2012;9:259. [ Links ] 54. Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, et al. Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia.

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Microglia Research Papers

These results suggest that nigral neuronal damage, regardless of etiology, may release aggregated alpha-synuclein into substantia nigra, which activates microglia with production of proinflammatory mediators, thereby leading to persistent and progressive nigral neurodegeneration in PD.

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Aggregated -synuclein activates microglia: a process ...

The FASEB Journal • Research Communication Aggregated -synuclein activates microglia: a process leading to disease progression in Parkinson's disease Wei Zhang,*,† Tongguang Wang,* Zhong Pei ...

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MHCII Is Required for α-Synuclein-Induced Activation of ...

 · In vitro, treatment of microglia with aggregated α-syn leads to activation of antigen processing and presentation of antigen sufficient to drive CD4 T-cell proliferation and to trigger cytokine release. These results indicate a central role for microglial MHCII in the activation of both the innate and adaptive immune responses to α-syn in PD ...

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The gamma chain subunit of Fc receptors is required for ...

 · The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopamine-producing (DA) neurons in the substantia nigra (SN), has an important role in the pathogenesis of Parkinson's disease (PD). Previous studies have shown that neuroinflammation plays a key role in PD pathogenesis. In an AAV-synuclein mouse model of PD, we have found that over-abundance of α …

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Alpha Synuclein Research Papers

These results suggest that nigral neuronal damage, regardless of etiology, may release aggregated alpha-synuclein into substantia nigra, which activates microglia with production of proinflammatory mediators, thereby leading to persistent and progressive nigral neurodegeneration in PD.

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Proteomic Studies of Nitrated Alpha-Synuclein Microglia ...

Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells ... Deleterious microglial activation is postulated to affect a neurodegenerative process in PD. ... Miller DS, Wu X, Block ML, Wilson B, Zhou Y, Hong JS, Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in ...

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Concise Review: Modeling Neurodegenerative Diseases with ...

Microglia, the resident macrophage cells of the brain, have also emerged as key players in neuroinflammation. As primary human microglia from living subjects are normally not accessible to researchers, there is a pressing need for an alternative source of authentic human microglia which allows modeling of neurodegeneration in vitro.

get price

image

Nitrated alpha-synuclein-activated microglial profiling ...

This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alpha-synuclein (α-syn), a chief component of Lewy bodies that is released from affected dopaminergic neurons. α-Syn is ni-trated during oxidative stress responses and in its aggregated form, induces inflammatory microglial functions.

get price

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Differential Roles of M1 and M2 Microglia in ...

 · In this review, we focus on the potential role of M1 and M2 microglia and the dynamic changes of M1/M2 phenotypes that are critically associated with the neurodegenerative diseases. Generally, M1 microglia predominate at the injury site at the end stage of disease, when the immunoresolution and repair process of M2 microglia are dampened.

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